Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol
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چکیده
منابع مشابه
Acute adverse reactions attributed to allopurinol in hospitalised patients.
Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients, 0.6%) and diarrhoea and drug fever (5 each, 0.3%). Adverse effects were dose...
متن کاملAllopurinol-induced severe cutaneous adverse reactions.
In their article entitled ‘Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin’, Chung and colleagues elegantly investigated the factors associated with severe cutaneous adverse reactions (SCAR) in patients taking allopurinol as antihyperuricaemic agent and found that impai...
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15 صفحه اولCost-effectiveness Analysis for Genotyping before Allopurinol Treatment to Prevent Severe Cutaneous Adverse Drug Reactions.
OBJECTIVE Patients with an HLA-B*58:01 allele have an increased risk of developing severe cutaneous adverse drug reactions (SCAR) when treated with allopurinol. Although one-off pharmacogenetic testing may prevent life-threatening adverse drug reactions, testing prior to allopurinol initiation incurs additional costs. The study objective was to evaluate the cost-effectiveness of HLA-B*58:01 scr...
متن کاملAdverse reactions to radiopharmaceuticals.
This review covers the side effects and adverse reactions to radiopharmaceuticals that were reported in the literature over the past 25 years. The information published prior to 1970 is sporadic, but due to the increased utilization of nuclear medicine procedures and the recognition that radiopharmaceuticals may have pharmacologic side effects, a registry has existed since 1971 to tabulate info...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1988
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780310318